This leads to a decreased number and functionality of Treg, gamma-delta T cells (γδT), CD8+ memory T cells and NK cells, along with B cell hyperactivity and elevated IgE [43,78,81,82] and reduced postnatal growth, with patients presenting with immunodeficiency and autoimmunity, characterized by chronic infections, diarrhea and eczema along with short stature, with patients with the AD form having milder symptoms, particularly with respect to immunodeficiency [77,80]. Here, IGHE is linked to immunodeficiency disease.