Based on the wider and underscored occurrence of IGF-II secretion among solid malignancies, independently from the circulating levels clinically associated with hypoglycemia, we find it to be more appropriate to classify tumors as either IGF-II-secreting tumors (IGF-IIsT) or non-IGF-II-secreting tumors (non-IGF-IIsT). The gene discussed is IGF2; the disease is Hypoglycemia.