IGF2 and neoplasm: A second seminal study clearly linking (a) endogenous tissue focal expression and cancer-secretion of IGF-II (b) with the tumor malignant switch was published by Christofori et al. [15] using an invaluable genetic mice model initially developed by Hanahan et al. [33,34] that recapitulated the stage progression features and requirements of pancreatic carcinoma.