The phenotypic spectrum associated with SCN2A has largely expanded since, as variants have also been reported in patients with epilepsy of infancy with migrating focal seizures (EIMFS), infantile spasms, episodic ataxia 9, Ohtahara syndrome, developmental and epileptic encephalopathy 11 (DEE11) and other non-specific epileptic phenotypes. Here, SCN2A is linked to early-infantile DEE.