TPP1 and B-cell chronic lymphocytic leukemia: p.Tyr36Cys, previously reported at somatic level in CLL cases [46,47], was predicted by a structural prediction tool to impact POT1 and telomeric DNA affinity, whereas c.1164-1G>A, p.Gln358SerFTer13, and p.Gln376Arg were predicted to impair POT1-TPP1/ACD interaction.