One study reported that whole-exome (WES) and whole-genome sequencing (WGS) performed on a total amount of 6558 cases of ColoRectal Cancer (CRC) allowed to find in three different cases three POT1 variants: the aforementioned p.D617Efs*9, p.Arg363Ter, and p.Asn75LysfsTer16 [26]. Here, POT1 is linked to colorectal cancer.