POT1 and cancer: The sparseness of data regarding POT1 variants, and the spectrum of POT1–TPD, also points out the need for wide and systematic studies, including statistical validations, one of the strongest methods of confirming a “cancer risk”, as recently performed in a retrospectively analysis of the results derived from multigene panel testing applied on a large cohort of patients (13.315) evaluated for various cancer predisposition syndromes.