Regarding a potential upstream cause of this early inflammation pattern in the cerebellum, we reasoned that the widespread presence of DAMPs, excessive generation of ROS, and lipid peroxidation reported in NPC, which are associated with membrane damage at the mitochondria and the aberrantly enlarged endolysosomal compartments [14,15,16,17,18], could be triggering sterile inflammation patterns through NF-kB and toll-like receptor signaling pathways, leading to interferon signaling. This evidence concerns the gene NFKB1 and nasopharyngeal carcinoma.