FOXA1 cooperates with Estrogen Receptor-1 (ESR1) in regulating the gene expression in ER-positive luminal breast cancer cells, as evidenced by a clinical data analysis indicating that high levels of FOXA1 improve the survival of ESR1Low patients, but worsen the survival of ESR1High patients of breast cancer [36]. The gene discussed is FOXA1; the disease is breast carcinoma.