RPA1 and neoplasm: The study of the Notch activation-induced tumor in Drosophila larval salivary glands has shown that genes involved in DNA damage response and repair including mei-41 (the Drosophila homolog of ATR), RpA-70 (the Drosophila homolog of RPA1), Mre11, and Rad50 are significantly upregulated in the polyploid tumors.