EGFR and autosomal dominant polycystic kidney disease: The development of ADPKD is linked to the malfunction of PC1 and/or PC2 proteins, which can affect various signaling pathways such as planar cell polarity (PCP), mammalian target of rapamycin (mTOR), G-protein coupled receptor (GPCR), epidermal growth factor receptor (EGFR), cystic fibrosis transmembrane conductance regulator (CFTR), Wnt, mitogen-activated protein kinase (MAPK), cellular Ca2+, and the cell cycle [22].