We identified a nominal association between the instrumented levels of CSF C1-esterase inhibitor and the odds of having a ‘rash and other nonspecific skin eruption’ (odds ratio [OR]: 1.13, 95% CI: 1.05 to 1.22, p = 8.49 × 10−4) in keeping with the known clinical syndrome of C1-esterase inhibitor deficiency (Supplementary Table S8). Here, C1S is linked to hyperinsulinemic hypoglycemia, familial, 4.