Firstly, among all 153 leading-edge genes, a total of 33 leading-edge genes (ACOXL, CRAT, SESN2, ABCD1, HSD17B10, ECH1, ECHS1, ETFB, ABCB11, SORT1, C1QTNF12, PEA15, SLC27A4, INSR, PC, IDH3G, IDH3B, SDHB, ACO2, SUCLG1, PGM1, HK1, ALDOC, ALDH2, PFKL, ENO1, PFKP, AKR1A1, CYC1, SDHA, NUP210, PPP2R1A, and HK2) were significantly associated with the OS of AML patients (p < 0.05) by univariate Cox regression analysis. Here, PPP2R1A is linked to acute myeloid leukemia.