Firstly, among all 153 leading-edge genes, a total of 33 leading-edge genes (ACOXL, CRAT, SESN2, ABCD1, HSD17B10, ECH1, ECHS1, ETFB, ABCB11, SORT1, C1QTNF12, PEA15, SLC27A4, INSR, PC, IDH3G, IDH3B, SDHB, ACO2, SUCLG1, PGM1, HK1, ALDOC, ALDH2, PFKL, ENO1, PFKP, AKR1A1, CYC1, SDHA, NUP210, PPP2R1A, and HK2) were significantly associated with the OS of AML patients (p < 0.05) by univariate Cox regression analysis. Here, NUP210 is linked to acute myeloid leukemia.