Thus, we highlight some important roles for Rpl3l in the development of cardiomyopathy, as the results of our analysis have demonstrated a strong association of Rpl3l-correlated genes with these important pathways that are involved in the cardiac pathophysiology of the human and mouse, while the involvement of the Rpl3l-correlated genes in the development of DCM requires further confirmation through knock-in and knock-out experiments. The gene discussed is RPL3L; the disease is familial dilated cardiomyopathy.