KMT2D and CHARGE syndrome: To test whether our mice had inner ear abnormalities similar to those seen in CHARGE syndrome (for example the commonly reported Mondini dysplasia—reduced length and number of cochlear turns), we performed microcomputed tomography (micro-CT) imaging and created 3D reconstructions of the inner ear in both Kmt2d+/βGeo mice (n = 6) and WT littermates (n = 6) (Figure 3A).