In a biological screening assay focused on PD candidate genes involved in PINK1-dependent mitophagy, knockdown of both KANSL1 and KAT8 resulted in reduced accumulation of phospho-ubiquitin, an initiation marker of PINK1-dependent mitophagy, suggesting KANSL1 plays a role in mitophagy regulation and PD pathology [31,33]. This evidence concerns the gene PINK1 and Parkinson disease.