At present, pathogenic variants in the CFTR gene, along with other genes causing most common autosomal recessive (CF, phenylketonuria, spinal muscular amyotrophy, and others) and common X-linked recessive diseases (Duchenne/Becker muscular dystrophy, hemophilia A and B, and others), are actively screened in fertile individuals and couples, as well as in patients planning to undergo IVF/ICSI. Here, CFTR is linked to cystic fibrosis.