Furthermore, an innate and adaptive immunity dysfunction leading to autoinflammation has been reported to play a pivotal role with upregulation of proinflammatory cytokines such as Interleukin (IL)-1β and IL-17, chemokines, and tumor necrosis factor (TNF)-α both in lesional skin and in serum of HS patients [1,7,8]. The gene discussed is TNF; the disease is histiocytic sarcoma.