The second most commonly mutated genes were MAGI2 and NOTCH1, mutated in tumors from four patients, and seven genes (RB1, CREBBP, COL5A2, PLXNC1, PDZRN4, LIPI and DNAH5) were mutated in tumors from three patients, with no other gene mutated in more than two patients in this tumor set, reflecting the genomic heterogeneity of TNBC tumors (Figure 2). The gene discussed is RB1; the disease is neoplasm.