Some slightly different responses elicited by TRIB2 overexpression in MKN45 and NCI-N87 cells were most likely due to their different genetic backgrounds, including somatic mutations as well as histopathological features of tumors of origin (MKN45 have been derived from a diffuse GC, while NCI-N87 from a GC of the intestinal type). Here, TRIB2 is linked to gastric cancer.