As ccRCCs are also usually resistant to targeted therapies, we investigated the impact of MUC1 expression on renal cancer cell responses to four multi-targeted receptor TKIs: (i) cabozantinib, an inhibitor of VEGFR, Axl, and Met; (ii) crizotinib, an inhibitor of ALK and c-Met; (iii) dovitinib, an inhibitor of VEGFR, FGFR, and FLT3/c-Kit; and (iv) sunitinib, an inhibitor of VEGFR and PDGFR. This evidence concerns the gene ALK and renal carcinoma.