In a study conducted by Talhouk et al. [38], tumors with abnormal p53 protein were G3 tumors in 96% of cases, non-endometrial tumors in 80.2% of cases, LVSI infiltration was found in 61% of cases, and had a high rate of lymph node metastasis. This evidence concerns the gene TP53 and metastatic malignant neoplasm in the lymph nodes.