However, investigation of cytokine cascades in both sepsis and acute exercise (not specified as resistance or aerobic) revealed a key difference in that pro-inflammatory cytokines TNF-α and IL-1β are present first in sepsis before the release of anti-inflammatory cytokines IL-6, TNF-R, IL-10, and IL-1ra [194]. The gene discussed is TNFRSF1A; the disease is Sepsis.