Pathway enrichment of candidate driver mutated genes is shown as a bar graph in Figure 2A. Significant pathways of driver genes are highly cancer-related pathways, such as EGFR tyrosine kinase inhibitor resistance, PD-L1, and PD-1 pathways in cancer, prostate cancer, pancreatic cancer and chronic myeloid leukemia pathways. The gene discussed is CD274; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.