A study by Izycka-Swieszewska et al. demonstrated that tumors with higher ERBB2 expression had a better prognosis than tumors with low or no expression [163], while a study by Wilzen et al. showed that high expression of ERBB3 was associated with a high expression of ERBB2, and that the expression profile of NB was more related to nonaggressive GNB and ganglioneuroma [164]. This evidence concerns the gene ERBB2 and ganglioneuroma.