Many are designed to bring immune cells in proximity with tumor cells by targeting both immune markers (CD137/4-1BB, CD27, PD-1, OX-40) and tumor markers (B7-H3, CD47, PD-L1, 5T4, ROR1, claudin, GPC3, HLA-G, PSCA). The gene discussed is PDCD1; the disease is neoplasm.