The authors showed that PCA3 demonstrated a better predictive ability for PC detection among patients with a low suspicion score on MRI, and using the strategy of performing a biopsy in cases with a PCA3 score > 35 would miss only 4.9% of csPC (Gleason score ≥ 4 + 3) [43]. The gene discussed is PCA3; the disease is pachyonychia congenita.