In another four patients, there was a variant of uncertain significance: APC p.D1711V/Class 3 (one patient with polyposis), BRCA2 p.E170A/Class 3 (one patient with breast cancer and nonpolyposis colorectal cancer), BRCA2 Class 3 (one patient with ovarian cancer) and ATM c.720T>C/Class3 (one patient with breast cancer). The gene discussed is APC; the disease is colorectal cancer.