This includes archetypal BCR::ABL1-mediated CML [59], as well as the various Ph− MPNs caused by GOF mutations in JAK2 [60], MPL [61], and CALR [41], with chronic STAT3 activation potentially more relevant for GOF mutations in CSF3R [62]. Here, ABL1 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.