Thus, knockdown of the STAT5 genes abrogated cell survival in cell line models of BCR-ABL1 and JAK2 V617F [64], while ablation of mouse Stat5 was shown to reduce the severity of MPN induced by either BCR-ABL1 or JAK2 V617F [65,66]. The gene discussed is BCR; the disease is myeloproliferative neoplasm.