The ablation of Stat3 resulted in an altered JAK2 V617F phenotype, with decreased neutrophilia, although thrombocytosis was enhanced [67], while the ablation of Stat1 actually exacerbated JAK2 V617F-induced erythrocytosis in a mouse model despite reducing the thrombocytosis [68]. This evidence concerns the gene STAT3 and thrombocytosis disease.