Similarly, the compound 17f was also able to inhibit phosphorylation of STAT5 (but not STAT3) and growth in both CML and AML cell lines [89], while ISST5-002 prevented STAT5 phosphorylation and dimerization in response to JAK2 V617F and BCR-ABL1 [90]. The gene discussed is STAT5A; the disease is acute myeloid leukemia.