Specifically, we found 6 genes for HNSCC (AOX1, NMNAT2, ENPP3, NADK, CD38, and PARP1), 11 genes for LuSCC (AOX1, NNMT, NMNAT2, NMNAT3, ENPP2, ENPP3, NMRK2, NADSYN1, SIRT1, CD38, and PARP1) and 11 genes for CeSCC (AOX1, NMNAT3, ENPP1, ENPP2, ENPP3, NMRK2, PNP, NADSYN1, SIRT1, SIRT3, and CD38);. The gene discussed is ENPP1; the disease is head and neck squamous cell carcinoma.