Furthermore, CeSCC was well discriminated by ENPP1 (AUC = 0.9715; p < 0.0001), PNP (AUC = 0.8622; p < 0.0001), and SIRT3 (AUC = 0.9072; p < 0.0001), different from HNSCC (ENPP1:AUC = 0.5522; p = 0.2505; PNP:AUC = 0.6740; p = 0.001; SIRT3:AUC = 0.6249; p = 0.006) and LuSCC (ENPP1:AUC = 0.6353; p = 0.0018; PNP:AUC = 0.5128; p = 0.7671; SIRT3: AUC = 0.6272; p = 0.0033). Here, PNP is linked to head and neck squamous cell carcinoma.