As shown in Figure 5A, the signature combining the expression values of AOX1 and SIRT3 was able to discriminate stage 1 from stage 2 HNSCC samples (AUC = 0.7154, p = 0.0014) and stage 1 from stage 3 (AUC = 0.730, p = 0.0005). Here, AOX1 is linked to head and neck squamous cell carcinoma.