Nonetheless, it is interesting to note that mutations in FGFR3 and FGFR4, pluripotency signaling, and developmental genes have been identified in hepatocellular neoplasms that have not otherwise specified (HCN NOS) particularly challenging liver tumors with combined or overlapping histological features of hepatoblastoma and hepatocellular carcinoma observed in late pediatric age [17]. The gene discussed is FGFR4; the disease is hepatocellular carcinoma.