P1 had a recurrence of FLC two years after the resection; P2 died six months after the resection due to the rapid recurrence and progression of HCC; P3 is alive without any recurrence; P4 died one year after the histological diagnosis of HCC due to the progression of an intractable tumor; and P5 is alive and he presented other small nodules with low AFP during the follow up. The gene discussed is AFP; the disease is neoplasm.