Specifically, they found that inhibition of tumor-expressed protein phosphatase-2A (PP2A), a serine-threonine phosphatase involved in DNA damage response and inhibition of which had previously been shown to enhance tumor immunity [130,131], leads to the accumulation of cytosolic double-stranded DNA and consequent induction of the cGAS-STING pathway. Here, PTPA is linked to neoplasm.