Many topics still need to be thoroughly investigated in SARS-CoV-2 pathogenesis; in this sense, genetic features (e.g., the influence of P1245 polymorphic variants of HSD3B1 genes on COVID-19 severity) may contribute to explain the heterogeneous disease course of COVID-19 in different patients and more studies should therefore be encouraged in this direction [122]. The gene discussed is HSD3B1; the disease is COVID-19.