Since low SOCS1 gene expression correlates with poor prognosis in the TCGA-liver hepatocellular carcinoma (LIHC) dataset [32], and high GCLC in HCC tissues correlates with poor prognosis [58], we evaluated the relationship between SOCS1, NFE2L2 (NRF2) and GCLC gene expression in the TCGA-LIHC dataset. The gene discussed is SOCS1; the disease is hepatocellular carcinoma.