To study the impact of SOCS1 expression on antioxidant responses in HCC cells, we treated the murine Hepa1-6 (Hepa) hepatoma cell line stably expressing SOCS1 (Hepa-SOCS1) or the empty vector (Hepa-Vector) with cisplatin or t-BHP, which are known to induce oxidative stress [44,45,46,47,48,49,50,51,52,53]. This evidence concerns the gene SOCS1 and hepatocellular carcinoma.