CSF-1R expression was up-regulated in a 5-FU chemo-resistant population of CRC cells [54], and the acquisition of the resistant phenotype, as well as the expression of stem-like and EMT-related genes, was linked to the down-regulation of Mir-34a, thereby suggesting that the CSF-1R/mir-34a pathway could be a potential target against CRC chemoresistance and invasiveness [54]. This evidence concerns the gene CSF1R and colorectal carcinoma.