An in vivo study demonstrated that CSF-1R inhibition negatively affected the invasiveness potential of claudin-low breast cancer cells; a tumor derived from mice orthotopically injected with CSF-1R-depleted breast cancer cells showed decreased invasive ability and reduced lung metastases as compared to controls, thereby suggesting the crucial role of CSF-1R in cancer cell motility and invasion [46]. This evidence concerns the gene CSF1R and cancer.