SMAD4 and dedifferentiated liposarcoma: MiR-193 family members were found to be downregulated in DDLPS compared with normal fat, and miR-193 expression is considered a favorable prognostic factor in WDLPS/DDLPS [76], as well as a therapeutic approach, as miR-193 targets PDGFRβ, SMAD4 and YAP1, belonging to strongly interacting pathways (focal adhesion, TGFβ and Hippo, respectively) [77].