The expression of the E3-ubiqutin ligase gene SIAH2 in DDLPS tumor-associated macrophages and other stromal cells indicates that SIAH2 expression may serve as a molecular marker distinguishing between DDLPS and WDLPS, but more complete evaluation of the role of SIAH2 in the DDLPS phenotype is limited by the availability of fresh tissues from these rare cancers [49]. This evidence concerns the gene SIAH2 and neoplasm.