A number of the genetic abnormalities are specific to the whole set of LPSs: TOP2A, PTK7 and CHEK1 were overexpressed in 140 cases of liposarcoma [17]; point mutations in CTNNB1, CDH1, FBXW7 and EPHA1, C-MET and EGFR amplification and increased expression of C-KIT, EGFR, PD-L1 and PD-1 also represent potential oncogenic events in liposarcoma cells [18]. The gene discussed is TOP2A; the disease is liposarcoma.