EFEMP1 and metastatic malignant neoplasm in the lymph nodes: The EFEMP1 gene encoding fibulin-3, a member of the extracellular matrix glycoprotein family associated with lymph node metastasis, vascular invasion and poor prognosis, was also found to be hypermethylated and downregulated in MLPS compared to normal fat [71,93,94,95].