Subsequent study demonstrated that DNA damage response induced by chemotherapy and molecular targeted therapy upregulated the expression of major histocompatibility complex (MHC) class I associated chains A (MICA) in HCC cells through IRF1 mediation [9], and increased the number of natural killer (NK) cells and CD8+ T cells through the activation of natural killer group 2D (NKG2D) receptors [10]. The gene discussed is IRF1; the disease is hepatocellular carcinoma.