To study these issues further, we evaluated the gene expression of the following important factors: (1) STAT3, a possible master regulator for 3D spheroid formation [28]; (2) KRAS and SOX2, possible regulators of the induction of deformity in MM cell lines [27]; (3) PGC1a, the main regulator of mitochondrial biogenesis [29]; and (4) HIF1a, a major hypoxia transcriptional regulator [30], among A357, WM266-4, and Skmel-24 cells (Figure 5). The gene discussed is HIF1A; the disease is Miyoshi myopathy.