Currently, there are important advances in this area, with important limitations, probably due to the heterogeneity of gene regulation in MM; in addition, a flow cytometry analysis of phosphorylation profiles showed that the activation patterns of signaling pathways such as Stat-3 and MAPK p38 in cells from MM patients and MM cell lines are heterogeneous [129]. This evidence concerns the gene MAPK1 and Miyoshi myopathy.