Recent studies have shown that the mechanism of action of 8-NH2-Ado, at least in MM, is the inhibition of the phosphorylation of many proteins, such as ERK1/2, Akt and p38, and because of this, the inhibition of the phosphorylation of these proteins is the induction of apoptosis in these MM cell lines treated with 8-NH2-Ado [83]. Here, MAPK14 is linked to Miyoshi myopathy.