It was found that frequencies of genomic alterations among MAGEA family members in bladder cancer were MAGEA1 1.8%, MAGEA2 1.6%, MAGEA3 1.9%, MAGEA4 1.6%, MAGEA6 2.6%, MAGEA8 1.7%, MAGEA10 2%, MAGEA11, 2.1%, and MAGEA12 2.4% (Figure 3A). This evidence concerns the gene MAGEA4 and urinary bladder cancer.