AKT1 and urinary bladder carcinoma: For example, a combination of carbonic anhydrase inhibitor, acetazolamide (AZ), and SFN is suggested to potentially suppress cell proliferation and enhanced apoptosis in HTB-9 and RT112(H) bladder cancer cell lines by suppressing Akt signaling proteins such as p-Akt, p-mTOR and p-S6 [43].