HDAC9 and breast carcinoma: Similarly, the combination of SFN, GEN and sodium butyrate (SFN-GEN-NaB) was found to prevent the development of breast cancer mainly by regulating epigenetic modifications through the suppression of DNA methyltransferase (DNMT), HDAC, histone H3 methylations and inducing the activity of histone acetyltransferases [80].