CASP3 and familial pancreatic carcinoma: Moreover, SFN in combination with heat shock protein 90 (Hsp90) inhibitor, 7-allylamino 17-demethoxygeldanamycin (17-AAG), potentially sensitized Mia Paca-2 pancreatic cancer cells by reducing their proliferation through the suppression of Hsp90, Raf-1, and Akt while inducing caspase-3 activity [115].