SFN and glioblastoma: In line with this, SFN was demonstrated to function as a chemosensitizing agent in temozolomide (TMZ)-resistant glioblastoma cells by enhancing TMZ-induced apoptosis through the modulation of caspase-3, Bcl-2 and Bax expressions as well as suppression of miR-21 levels via Wnt/β-catenin signaling [44].