NFKB1 and colorectal carcinoma: For instance, co-treatment with SFN and the flavonoid apigenin in Caco-2 CRC cell line synergistically amplified the induction of phase II detoxification enzymes, notably glutathione and UDP-glucuronosyltransferases A1 (UGTA1), via the modulation of ERK and NF-κB translocation, thus signifying its chemopreventive potential [92].