AKT1 and cancer: Furthermore, combinations of SFN with diverse chemotherapy agents and other phytochemicals have been shown to modulate several resistance-related pathways, including MAPK, Akt, NF-κB, signal transducer and activator of transcription 3 (STAT3), and various molecules such as p53, retinoblastoma protein (RB), cyclins, cyclin-dependent kinases (CDKs), matrix metalloproteinases (MMPs), caspases, across different cancer types [48,49,50,51,52].