PRKAR1A and central nervous system cancer: The average numbers of PRKAR1A mRNA copies in glioma G3 patients (Me = 602,700.25 copies/μg RNA), as well as in glioma G4 patients (Me = 548,360.50 copies/μg RNA), were significantly higher compared to G2 grade (Me = 327,519.69 copies/μg RNA) (p = 0.029 and p = 0.003, respectively) (Figure 3A).