EGFR and central nervous system cancer: In contrast, in patients with G4 grade, the mean levels of MAP2K2 mRNA (Me = 48,071.09 copies/μg RNA), as well as EGFR mRNA (Me = 29,540.14 copies/μg RNA), were significantly lower (p = 0.036 and p = 0.004, respectively) compared to the mean mRNA levels of glioma patients with G2 grade (Me = 111,980.19 and Me = 160,789.13 copies/μg RNA, respectively) (Figure 3B,C).