The most commonly occurring genetic disturbances in gliomas involve the deregulation of tyrosine kinase receptors, such as the epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor (PDGFR), and their aberrant signaling through the phosphatidylinositol-3 kinase (PI3K) signaling pathway and the mitogen-activated protein kinase (MAPK) pathways, ultimately leading to malignant transformation [29]. The gene discussed is WNK2; the disease is glioma.