In another in vitro study by Nicoletti et al. [21], conducted on the human glioblastoma cell lines U-138MG and U-251MG, it was shown that the stimulation of B1R and B2R through kinin receptor agonists activates the PI-3/Akt kinase and ERK kinase pathways, leading to the proliferation of glioblastoma cells. This evidence concerns the gene PI3 and glioblastoma.