In patients with G4 grade glioma, the copy number of BDKRB1 mRNA copies/μg RNA (Me = 890.10 copies/μg RNA) was significantly higher (p = 0.020) compared to the mRNA BDKRB1 level in patients with G2 grade (Me = 425.13 copies/μg RNA) (Figure 2A). Here, BDKRB1 is linked to central nervous system cancer.