Additionally, in contrast to the result that PANX1 releases ATP to promote immunogenic cell death, our study shows that, in lung adenocarcinoma, on the one hand, PANX1 may reduce immunogenic cell death by recruiting suppressor immune cells and promoting macrophage conversion to M2 type through cytokine pathways, and, on the other hand, these cytokines promote tumor cell survival and metastasis. This evidence concerns the gene PANX1 and neoplasm.