TRPV3 and diffuse palmoplantar keratoderma: While TRPV3 Gly573 mutation mice indicated the involvement of TRPV3 in itch, the Gly573 missense mutation was also discovered in Olmsted syndrome, which is a rare congenital disease characterized by skin hyperplasia, diffuse palmoplantar keratoderma, alopecia, and severe pruritus [85].