The correlation between NOTCH3-MMP3 axis activation and bone metastases induction [77], the pro-metastatic activity of EHF knockdown in PCa cells [78] and the involvement of SOX4 and EZH2 in enhancing the PCa cells invasiveness toward the activation of AKT and β-catenin pathways [11] have been experimentally demonstrated. This evidence concerns the gene EZH2 and posterior cortical atrophy.