The ROC curve analysis of multidimensional datasets including transcriptomic and clinical data of PCa tissues from the Prostate Adenocarcinoma study (MSK, Cancer Cell 2010) revealed that the transition to the metastatic phenotype was significantly associated with overexpression of AR, EZH2, NOTCH3, ZIC2 and SOX4 genes and downregulation of ALDH3A2, EHF, EPHA3, KLK3, SORD, XBP1, ADAMTS1 and PRDM5 genes (Figure 2B). The gene discussed is NOTCH3; the disease is cancer.