The PCa progression toward the androgen-refractory state was exclusively correlated, in agreement with previous studies [79,80,81], with low expression levels of ALDH3A2 and increased expression of NOTCH1, NOTCH4 and QKI (Figure 8), that significantly identified patients with poor prognosis (Figure 2B,C). Here, NOTCH4 is linked to posterior cortical atrophy.