Taken together, these results suggested that there is a set of genes (AR, EZH2, FOXA1, HOXB13, HOXA13, KLK3, EHF, SORD, SPON2, ADAMTS1, ETV1 and SMAD2) involved in modulating different transcriptional programs that may determine the phenotype-specific expression profile during PCa progression. Here, SMAD2 is linked to posterior cortical atrophy.