ICAM1 and Sepsis: In conclusion, this study has shown that GdCl3 pretreatment in mice with CLP-induced sepsis decreases the protein expression of ICAM-1 in the liver and its immunoreactivity in LSECs but increases ICAM-1 protein expression in the lung and its immunoreactivity in pulmonary endothelial cells compared to CLP-induced mice without GdCl3 treatment.