SNCA and Parkinson disease: Although the precise mechanism behind the loss of DAergic neurons in the SNPC is still not completely understood [26], the onset and development of PD may be influenced by misfolding in proteins and their accumulation [27], oxidative stress [28], mitochondrial dysfunction [29], energy deficiency [30,31], excitotoxicity [32,33], cell-autonomous processes [34,35], prion-like propagation of α-synuclein (α-syn) [36,37], protein clearance pathways malfunctioning [38,39], and corticostriatal pathogenesis [40].