STAT1 and Alzheimer disease: Consistent with our transcriptomic profiling of groups of mice with the same genotypes and AAV treatments, in the present study, we observed up-regulated STAT1 protein in 5xFAD, which was reported in human AD [55], whereas DUPS4 overexpression in 5xFAD female mice down-regulated STAT1 protein expression (Supplementary Data S2).