The top-ranked kinase PTM sets are KINASE-PSP_CAMK2A/Camk2a, KINASE-PSP_ERK1/Mapk3, and KINASE-PSP_JNK1/Mapk8 [51] (Figure 3G), which are critical in AD neuropathogenesis. This evidence concerns the gene CAMK2A and Alzheimer disease.