DUSP4 and Alzheimer disease: Overall, we observed significant overlaps between the 5xFAD- and DUSP4-associated signatures of both protein and phosphoprotein in female and male mice (Figure 2D and Figure 3C; Supplementary Figures S3B and S7A), but in the opposite directions, indicating that DUSP4 overexpression may reduce AD-related deficits by reversing the dysregulated genes/proteins in 5xFAD in comparison with WT in a sex-specific manner.