Thus, for example, the positive association between HMGCR and the downstream GGPS1, observed in normal tissue, disappeared in DCIS, and the positive association between GGPS1 and SQLE, which regulate, respectively, the production of isoprenoids and the irreversible commitment to CHOL [96], switched to a negative one. The gene discussed is GGPS1; the disease is ductal breast carcinoma in situ.