Given the role played by the Hippo signaling pathway in controlling the growth of normal cells, it is not surprising that the disruption of this pathway leads to the constitutive activation of YAP/TAZ, which in turn promotes uncontrolled proliferation and tumorigenesis [66,71], and the finding that common solid tumors, including breast cancer, show a high expression of YAP protein [72]. The gene discussed is YAP1; the disease is breast cancer.