ESRRA and neoplasm: Preclinical studies have shown that CHOL not only triggers metabolic switching through the activation of the ERRα pathway (see Section 2.2) but also contributes to cancer cell invasion by increasing tumor sphere formation [98] and the number of the cholesterol-enriched rafts [99], where the membrane-associated receptors for growth factors, adhesion molecules, and immunoregulatory molecules [100] are concentrated.