GJA1 and ischemia: On the other hand, the presence of the Cx43-S3E mutation clearly did not rescue propagation during ischemia (with CV before and after ischemia measuring 13.3 ± 1.9 cm/s and 5.4 ± 0.80 cm/s in Cx43-S3E hPSC-CMs versus 16 ± 3.0 cm/s and 6.5 ± 1.4 cm/s in WT cells) (Figure 3C).