AGER and intracerebral hemorrhage: Furthermore, in vivo, dietary supplementation with curcumin has been shown to reverse the microglial and astrocytes activation via NRF2/TLR4/NFkB/RAGE (receptor for advance glycation end products) signaling in a rodent model ethanol-induced neurotoxicity [68], and acts as an antioxidant in intracerebral hemorrhage, traumatic brain injury, quinoline acid-induced glutamate neurotoxicity, and ischemic injury models via the NRF2/HMOX1/AKT pathways [49,62,63,66,67,72].