C4B and cyclic hematopoiesis: The MD seems to also up-regulate factors involved in more advanced stages of CH differentiation, such as foxa2 [105,106], that prompt the expression of chondrocyte-proliferating population markers, while decreased transcriptional factors are involved in the terminal phases of CH differentiation and hypertrophy, such as mecf2c and mecf2d [107] (which furthermore seem to promote OC differentiation [108,109]).