By comparison with data obtained from different healthy donors (Figure 3), the Piezo1 MFI was increased, although non-significantly, in three out of the four spherocytosis patients (Figure 7C and Figure S10) and inversely correlated with the septin-to-ankyrin ratio and the spectrin membrane occupancy (Figure 7D,E). The gene discussed is PIEZO1; the disease is hereditary spherocytosis.