Moreover, our study opens the possibility to elucidate the deregulation of Piezo1–cytoskeleton–lipid domains interplay in patients with hereditary xerocytosis, characterized by Piezo1 mutations that induce an inherited disorder of erythrocyte dehydration [19,38], but also in Piezo1-related diseases such as beta-thalassemia and sickle cell disease. Here, PIEZO1 is linked to Beta-thalassemia.