To explore in more detail the mechanism behind the implication of the cytoskeleton in the control of Piezo1, we used RBCs from four splenectomized patients with hereditary spherocytosis, a disease mainly due to mutations in the genes coding for ankyrin or spectrin and characterized by a loss of RBC biconcavity and an impairment of RBC deformability [57,61,69,70]. The gene discussed is PIEZO1; the disease is hereditary spherocytosis.